Peripheral neuropathy can have a variety of causes, including:

1. Diabetes: High blood sugar levels can damage the nerves in the feet and hands.
2. Trauma: Physical injuries, such as from falls or accidents, can damage peripheral nerves.
3. Autoimmune disorders: Autoimmune disorders, such as lupus or rheumatoid arthritis, can cause inflammation that damages peripheral nerves.
4. Infections: Certain viral or bacterial infections, such as shingles, Lyme disease, or HIV, can damage peripheral nerves.
5. Vitamin deficiencies: Deficiencies in vitamins B1, B6, B12, or E can cause peripheral neuropathy.
6. Exposure to toxins: Exposure to toxins, such as heavy metals or chemicals, can damage peripheral nerves.
7. Alcoholism: Chronic alcohol abuse can damage peripheral nerves.
8. Hereditary factors: Some forms of peripheral neuropathy are hereditary and are caused by genetic mutations.

It’s important to note that in many cases, the cause of peripheral neuropathy is unknown.